The COVID-19 pandemic constitutes the largest global public health crisis in a century, with daunting health and socioeconomic challenges. Governments are taking unprecedented measures to limit the spread of the virus, ramping up health systems and restricting the movement of millions. The pandemic is severely disrupting access to life-saving sexual and reproductive health services. It is deepening existing gender inequalities, increasing gender-based violence, and worsening discrimination and barriers for marginalized groups. Sexual and reproductive health and rights is a significant public health issue that demands urgent and sustained attention and investment. UNFPA is providing this June 2020 revision to its Global Response Plan, to reflect upon the changing needs, align with partners, learn from UNFPA action already underway and to further focus UNFPA’s interventions. As the COVID-19 pandemic continues, new UNFPA research has shown the enormous scale of the negative unintended consequences and potential impact.